In molecular biology mir-765 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Traumatic Brain Injury
miR-765 has been identified as a diagnostic marker for traumatic brain injury (TBI), due to significantly elevated levels in the plasma of TBI patients. Furthermore, combination with either miR-16 or miR-92a allows extremely accurate distinction between TBI patients and healthy controls.
miR-765 and pheochromocytomas
Increased miR-765 expression is observed in Von Hippel-Lindau disease compared with the sporadic benign forms of pheochromocytomas. It has been linked to neuronal plasticity through the neurotrophic tyrosine kinase receptor type 3 (NTRK3) gene. A NTRK3 3'UTR variant, ss102661458, is located in a functional target site of miR-765 and is able to significantly affect miRNA-mediated NTRK3 regulation. Through this there is restoration of the altered gene expression by miR-765. NTRK3 is underexpressed with high or overexpressed levels of miR-765, thus pointing towards a possible involvement of this relationship in pheochromocytoma pathogenesis.
See also
- MicroRNA
References
Further reading
- Gu, H.; Li, H.; Zhang, L.; Luan, H.; Huang, T.; Wang, L.; Fan, Y.; Zhang, Y.; Liu, X.; Wang, W.; Yuan, Z. (2012). "Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects". Journal of Neurochemistry. 122 (3): 641–649. doi:10.1111/j.1471-4159.2012.07812.x. PMID 22642222.
- Della Vittoria Scarpati, G.; Falcetta, F.; Carlomagno, C.; Ubezio, P.; Marchini, S.; De Stefano, A.; Singh, V. K.; d'Incalci, M.; De Placido, S.; Pepe, S. (2011). "A Specific miRNA Signature Correlates with Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer". International Journal of Radiation Oncology, Biology, Physics. 83 (4): 1113–1119. doi:10.1016/j.ijrobp.2011.09.030. PMID 22172905.
- Guidi, M.; Muiños-Gimeno, M.; Kagerbauer, B.; Martí, E. L.; Estivill, X.; Espinosa-Parrilla, Y. (2010). "Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells". BMC Molecular Biology. 11: 95. doi:10.1186/1471-2199-11-95. PMC 3019150. PMID 21143953.
External links
- Page for mir-765 microRNA precursor family at Rfam
